COROSOLIC ACID
corosolic acid
CAS: 4547-24-4
Molecular Formula: C30H48O4
COROSOLIC ACID - Names and Identifiers
| Name | corosolic acid |
| Synonyms | Corosolic Corsolicacid Corosolic acid corosolic acid COROSOLIC ACID HYDROXYURSOLIC ACID 2-A-HYDROXYURSOLIC ACID 2ALPHA-HYDROXYURSOLIC ACID 2,3-DIHYDROXYURS-12-EN-28-OIC ACID (2a,3b)-2,3-Dihydroxy-urs-12-en-28-oic acid (2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid (2alpha,3beta,5xi,18alpha)-2,3-dihydroxyurs-12-en-28-oic acid |
| CAS | 4547-24-4 |
| EINECS | 610-253-4 |
| InChI | InChI=1/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1 |
COROSOLIC ACID - Physico-chemical Properties
| Molecular Formula | C30H48O4 |
| Molar Mass | 472.7 |
| Density | 1.14±0.1 g/cm3(Predicted) |
| Melting Point | 243～245℃ |
| Boling Point | 573.3±50.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1 in Py)+42.1 |
| Flash Point | 314.6°C |
| Solubility | Soluble in petroleum ether, benzene, chloroform, pyridine and other organic solvents, insoluble in water, soluble in hot ethanol, methanol. |
| Vapor Presure | 1.56E-15mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| pKa | 4.67±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.566 |
| MDL | MFCD06794973 |
| Physical and Chemical Properties | Soluble in petroleum ether, benzene, chloroform, pyridine and other organic solvents, insoluble in water, soluble in hot ethanol, methanol. From the flower Lagerstroemia indica (Lagerstroemia speciosa (L.) Pers.) |
COROSOLIC ACID - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2918195000 |
COROSOLIC ACID - Reference
| Reference Show more | 1. Zhou Shengqin, Jiang Qiong. Simultaneous determination of triterpene acids in different growth parts of lozenges tea by RP-HPLC method [J]. Chinese patent medicine 2015 37(3):570-573. 2. Hu Haobin. Determination of four kinds of triterpene acids in beilissu mixture by one-Test multi-evaluation method [J]. Journal of Nanjing University of Chinese Medicine 2015 000(003):277-279. 3. Huo Yuhang, Li Guantang, Liu Lili, etc. Analysis and Evaluation of six varieties of loquat leaves based on main functional components [J]. Food Science, 2019, 40(24). 4. Shi-Sheng Wang, Li-Juan Luo, Zhi-Gang Gao, Tong-Wei Guan, Wei-Jie Zhao, A convention synthesis of 2 β, Volume 24, Issue 7, 2013, Pages 617-618, ISSN 1 5. [IF=6.779] Shi-Sheng Wang et al."A convenient synthesis of 2β,3α-dihydroxyurs-12-en-28-oic acid as a natural diastereoisomer of corosolic acid."Chinese Chem Lett. 2013 Jul;24:617 6. [IF=5.646] Ma Bo et al."Corosolic acid, a natural triterpenoid induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3."J Exp Clin Canc Res. 2018 Dec;37(1):1-16 7. [IF=3.935] Li Li et al."Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC-MS and in silico docking."J Pharmaceut Biomed. 2019 Feb;164:241 8. [IF=3.935] Yong-Sheng Wu et al."Chemical profiling of Callicarpa nudiflora and its effective compounds identification by compound-target network analysis."J Pharmaceut Biomed. 2020 Apr;182:113110 9. [IF=3.638] Mengting Ni et al."Inhibitory effect of corosolic acid on α-glucosidase: kinetics, interaction mechanism and molecular simulation."J Sci Food Agr. 2019 Oct;99(13):5881-5889 10. [IF=1.175] Wang Meng et al."Mechanism of molecules crosstalk and the critical role of jasmonic acid on triterpenoid synthesis in Cyclocarya Paliurus cells under Aspergillus niger elicitor."J Plant Biochem Biot. 2022 Jan;:1-16 |
COROSOLIC ACID - Introduction
corosolic acid(Corrosive acid) is an inorganic acid with the chemical formula H2SO4. It is a colorless to light yellow, viscous liquid with a pungent odor. The following is a detailed description of the nature, use, formulation and safety information of corosolic acid:
Nature:
- corosolic acid is a strong acid that is highly corrosive and irritating.
-It has a strong water attachment ability, can release a lot of heat, and water reaction will produce violent splash and hot combustion.
- corosolic acid has strong oxidation and can react with many organic and inorganic substances.
Use:
- corosolic acid is a widely used chemical raw material and plays an important role in many industries such as pharmaceuticals, metallurgy, textiles, and electroplating.
-It can be used in battery manufacturing, such as lead-acid batteries.
-Used as a catalyst or solvent for organic synthesis reactions.
-Used to remove oxides and rust from metal surfaces.
Preparation Method:
- corosolic acid is mainly prepared by sulfur oxidation.
-Sulfur can be reacted with concentrated nitric acid to generate sulfuric acid and release nitrogen dioxide.
-The reaction process needs to control the temperature and concentration to ensure safety.
Safety Information:
- corosolic acid is a highly toxic chemical and must be used with caution.
-Wear protective glasses, gloves and protective clothing when using corosolic acid.
-avoid contact with skin, eyes and respiratory tract, such as accidental contact should immediately rinse with plenty of water.
-When storing corosolic acid, keep away from flammable and combustible materials to avoid fire or explosion.
-When operating and storing corosolic acid, strictly follow the relevant safety operating procedures to ensure a safe working environment.
Nature:
- corosolic acid is a strong acid that is highly corrosive and irritating.
-It has a strong water attachment ability, can release a lot of heat, and water reaction will produce violent splash and hot combustion.
- corosolic acid has strong oxidation and can react with many organic and inorganic substances.
Use:
- corosolic acid is a widely used chemical raw material and plays an important role in many industries such as pharmaceuticals, metallurgy, textiles, and electroplating.
-It can be used in battery manufacturing, such as lead-acid batteries.
-Used as a catalyst or solvent for organic synthesis reactions.
-Used to remove oxides and rust from metal surfaces.
Preparation Method:
- corosolic acid is mainly prepared by sulfur oxidation.
-Sulfur can be reacted with concentrated nitric acid to generate sulfuric acid and release nitrogen dioxide.
-The reaction process needs to control the temperature and concentration to ensure safety.
Safety Information:
- corosolic acid is a highly toxic chemical and must be used with caution.
-Wear protective glasses, gloves and protective clothing when using corosolic acid.
-avoid contact with skin, eyes and respiratory tract, such as accidental contact should immediately rinse with plenty of water.
-When storing corosolic acid, keep away from flammable and combustible materials to avoid fire or explosion.
-When operating and storing corosolic acid, strictly follow the relevant safety operating procedures to ensure a safe working environment.
Last Update：2024-04-10 22:29:15
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View History
COROSOLIC ACID
ACT-129968 (Setipiprant)
MAGNESIUM PHOSPHATE DIBASIC TRIHYDRATE
2-巯基-4-氨基-7H-吡咯[2,3-d]嘧啶
XWIHRGFIPXWGEF-LUIAAVAXSA-N
2-氨基-5-氯吡啶
2-碘-3-氨基吡啶
TISSUE EMBEDDING MEDIUM (PARAPLAST(R) REGULAR)
TRIPALMITIN, [PALMITIC-1-14C]
TETRAMETHYLAMMONIUM CHLORIDETETRAMETHYLAMMONIUM CHLORIDETETRAMETHYLAMMONIUM CHLORIDETETRAMETHYLAMMONIUM CHLORIDE
ACT-129968 (Setipiprant)
MAGNESIUM PHOSPHATE DIBASIC TRIHYDRATE
2-巯基-4-氨基-7H-吡咯[2,3-d]嘧啶
XWIHRGFIPXWGEF-LUIAAVAXSA-N
2-氨基-5-氯吡啶
2-碘-3-氨基吡啶
TISSUE EMBEDDING MEDIUM (PARAPLAST(R) REGULAR)
TRIPALMITIN, [PALMITIC-1-14C]
TETRAMETHYLAMMONIUM CHLORIDETETRAMETHYLAMMONIUM CHLORIDETETRAMETHYLAMMONIUM CHLORIDETETRAMETHYLAMMONIUM CHLORIDE